On 22 December 2011, a loss to Católica ended Universidad de Chile's unbeaten streak at 36. But they consoled themselves with their second of three straight league titles.
UDC, who won the 2011 Apertura Final over Católica the previous June, last lost on 13 July, falling 0-2 to Magallanes in the Copa de Chile. Afterward, they went on a tremendous run that included the Copa Sudamerica, which they won over LDU Quito on 14 December to extend their unbeaten run to 35 games in all competitions, bettering their 33-game streak from 1999. For their 36th game, they beat Católica 1-2 in the first leg of the 2011 Clausura semi-finals on 18 December, then hosted Católica for the second leg four days later.
After conceding a 42nd-minute goal to Católica's Kevin Harbottle, UDC drew level with a strike from Osvaldo González in the 59th minute. The game remained 1-1 until stoppage time, when José Luis Villanueva scored for the visitors to set the final margin as a 1-2 win for Católica.
Although the goal put the two teams levels on points and goal differential, UDC still advanced by virtue of having finished higher than Católica in the classification phase. They went on to defend their title successfully, beating Cobreloa in the final, then defended it again in the 2012 Apertura.